Behçet disease presenting with neurological complications immediately after conversion from conventional cyclosporin A to microemulsion formulation.

Formulation and Evaluation of Hydrogel-Thickened Microemulsion For Topical Delivery of Minoxidil

The available minoxidil formulations for topical application suffer with major drawback and requires repeated application. The present study was aimed to investigate the effect of microemulsions and microemulsion based hydrogel-systems (MEHs) for increased percutaneous penetration of minoxidil. Minoxidil microemulsions were developed by conventional titration method using oleic-acid as oil, twe...

Population pharmacokinetic analysis of the microemulsion formulation of cyclosporin A (Neoral®) in renal transplant patients

Pharmacokinetics of Cyclosporine from Conventional and New Microemulsion Formulations in Healthy Volunteers

The bioavailability of two microemulsion formulations of cyclosporine (Drug A, cyclosporine Neoral, Sandoz Pharma Ltd., Switzerland and Drug B, cyclosporine Bioral, Panacea Biotec Ltd., India) was compared in 12 healthy volunteers in a randomized, double blind, cross over manner. Blood cyclosporine levels were analyzed by high performance liquid chromatography. The peak concentration was 1600.6...

Cyclosporine microemulsion and tacrolimus are associated with decreased chronic allograft failure and improved long-term graft survival as compared with sandimmune.

Tacrolimus and cyclosporine in the microemulsion formulation Neoral have demonstrated improvements in acute rejection rates after renal transplantation compared with conventional cyclosporine formulation, Sandimmune. To evaluate whether these drugs are also associated with improvements in chronic allograft failure (CAF) rates, we retrospectively analyzed 32,040 primary renal allograft recipient...

Ciclosporin microemulsion preconcentrate treatment of patients with Behçet's disease.

PURPOSE The new microemulsion preconcentrate (MEPC) formulation of ciclosporin has been developed to reduce problems in intestinal absorption and to stabilize fluctuations in blood levels. A multicenter, open-label clinical trial of MEPC was conducted to assess its efficacy and safety in Behçet's disease patients with ocular involvement. METHODS The patient population comprised 17 de novo pat...